"what s up with you" in German What's up with you? Was ist denn mit dir los? Was fehlt Ihnen denn? Detailed translations for "what s up with you" What's up with you? 1. general What's up with you?(also: What's wrong with you?, What's the matter with you?) Was ist denn mit dir los? What's up with you? Source: opensubtitles.org Corpus by OPUS Request review Was ist denn mit dir los? 2. wrong What's up with you? Was fehlt Ihnen denn?