"run its course" in German to run its course seinen Lauf nehmen Detailed translations for "run its course" to run its course to run its course(also: to take its course) seinen Lauf nehmen This one seems to want to run its course until they're all dead. Source: opensubtitles.org Corpus by OPUS Request review Dieser hier scheint seinen Lauf nehmen zu wollen, bis alle tot sind.